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The Promises Treatment Centers, estimates that between five and 10 % of the patients at his treatment centers are treated with naltrexone. Those probably to receive it are people who have a history of early relapse—those who have been treated before and still have not been able to maintain sobriety for far more than thirty days. Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with fat loss and the people who go through it you ought to err along the side of caution and let the FDA do its job and demand some investigation be done in order that the public is aware of the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to earn money and that they would say almost anything to keep people on their own medications. Researchers discovered that participants using this drug to get a year, dropped excess weight within a month and have kept the weight off throughout the 56 weeks in the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of multiple active ingredient, which may make them more efficient and safer. Combo-pilling may be the newest fad or also the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular will be the fact that as of right now there aren't any long term prescription weightloss pills that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise blood pressure level and heart rate, and must not be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high blood pressure level, along with by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients on the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. From a psychiatric standpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior has been hijacked from the addiction, and malfunctions such that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus and the person engages in a "goal-directed behavioral response" that produces a "natural high"(Bostwick & Bucci, 2008).